Quick overview of the state of patents for psychedelics


Psychedelics are a class of psychoactive substances that produce changes in perception, mood and cognitive processes. Also so known as “hallucinogens”, reference to psychedelics is commonly meant to include substances such as Psilocybin (a.k.a. “magic mushroom”), MDMA (a.k.a. “extasy”) and LSD (Lysergic acid diethylamide).

Likely following the lead of the ongoing legalisation of cannabis in Canada, many U.S. states and other countries, the recent years have seen unprecedented investments and an increasing interest in research, production, and supply of psychedelics, particularly for potential medicinal uses.

The present article aims to provide a brief overview of the current situation from a patent perspective and to discuss about patenting strategies for these substances.

Patent filing activity

A very simple keyword search in patent databases using the terms “hallucinogenic” or “psychedelic” in either the Title, Abstract or Claims revealed a total a 189 patents (81 families) filed since 2011[1]. As shown in Figure 1 below, yearly patent filings are increasing, showing an exponential growth in the last three years.

Figure 1: Yearly patent filing for psychedelics

The subject matter covered by these issued patents or pending patent applications is broad and include new medical uses such as treatment of headaches, treatment of CNS disorders, depression, and food allergies to name a few. Patents documents also cover new compounds and derivatives, methods and vehicles for delivery, etc. Table 1 below provides a few recent examples of patent documents in this field.

Table 1: Recent patent documents relating to psychedelics

ApplicantPatent or patent application numberTitle
MINDSET PHARMA INC. .WO 2021/155470Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
WO 2021/155467 3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
YALE UNIVERSITYUS 2021/0236523Psychedelic treatment for headache disorders
CONCEPT MATRIX SOLUTIONSUS 2021/0015833Oral soft gel capsule containing psychedelic compound
SW HOLDINGS, INC.WO 2021/003467Metered dosing compositions and methods of use of psychedelic compounds
APOTHECA SYSTEMS INC.WO 2020/237394Method and system for personalizing and standardizing cannabis, psychedelic and bioactive products
COMPASS PATHFINDER LIMITEDWO 2020/212952Treatment of depression and other various disorders with psilocybin
GH RESEARCH LIMITEDWO 2020/169851Compositions comprising 5-methoxy-n,n-dimethyltryptamine (5-meo-dmt) for use in treating mental disorders
PALO ALTO INVESTORS LPUS 11,045,454Methods of treating food allergy conditions
ELEUSIS HEALTH SOLUTIONS US, INC.US 2021/0183519Methods and systems for enhancing safety of psychedelic drug therapies

Patenting strategies

For being patentable, an invention must be “new” and “inventive”. Since most common psychedelics are known for many years, it is not possible to patent these existing substances (i.e. lack of novelty).

Although the psychedelics in their natural form cannot be patented, there is still room for patent protection in this field. For instance, new medical uses of the existing compounds can be patented as well as new derivatives of the natural molecules. Additional patentable subject matter may also include novel delivery methods, novel formulations, novel synergistic combinations active ingredients, and novel dosage regimens. It may also be possible to patent the uses of the psychedelics within particular patient populations (e.g. genetic trait or biomarker).

Considering the patenting challenges, it will be very important for psychedelic developers to make sure they have sound strategies around intellectual property. Absence of intellectual property will most certainly make the company or project not so interesting for investors or commercial partners.


The interest in psychedelics is increasing and it looks like this field is poised to grow, following the path of cannabis legalization in Canada, many U.S. states and other jurisdictions. There is a rapidly increasing number of patents being filed for psychedelics and companies that are serious should develop early intellectual property strategies for protecting their innovations and also for making sure not to infringe someone else patents.

[1] Search carried out early September 2021. The search is not exhaustive since many relevant psychedelics-related patents likely do not comprise the particular keywords used. For instance, psychedelic parents may recite instead keywords such as” psilocybin”, “MDMA”, “LSD”, etc.

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